One of the Short-Chain Fatty Acids (SCFAs), Sodium Propionate, Can Reduce the Dosage of Sishen Pill in Regulating the Intestinal Microbiota in Diarrhea with Kidney-Yang Deficiency Syndrome.

Both the sodium propionate and Sishen Pill groups presented a decreasing trend in IL-6 levels, and notably, the serum TNF-α levels in both groups were significantly lower than those in normal group ( p < 0.01 or p < 0.05).

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Additionally, concerning natural recovery, the 75% dose of Sishen Pill combined with 60 mg/kg sodium propionate and Sishen pill group presented an increasing trend in the metabolic activity of ansamycin biosynthesis compared with normal group, with statistically significant differences observed between the 75% dose of Sishen Pill combined with 60 mg/kg sodium propionate and Sishen pill group and normal group ( Figure 9C ).

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