The ubiquitin ligase HUWE1 enhances WNT signaling by antagonizing destruction complex-mediated β-catenin degradation and through a mechanism independent of changes in β-catenin abundance.

PLoS Genet · 2025 · PMC12148233 · PMID 40424469

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highly significantno p-value reported

HUWE1 , the gene encoding the eponymous E3 ubiquitin ligase, was the most striking example of a hit that was highly significant in the CSNK1A1 suppressor but not the APC suppressor screen [ 15 ].

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