Exploiting FcRn engagement of an albumin-CpG oligonucleotide covalent conjugate for potent TLR9 immune induction.

The binding of the two rHA variants follows an expected trend, with the HB variant (EC 50 = 1.5 nM) exhibiting greater binding than WT (EC 50 = 134 nM). rHA-CpG WT binding (EC 50 = 10.4 nM) was higher than that of rHA WT, but lower than rHA-CpG HB (EC 50 = 0.7 nM).

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