Genetic predisposition of suicidal behavior: variants in GRIN2B, GABRG2, and ODC1 genes in attempted and completed suicide in two Balkan populations.

Notably, CC genotype of rs2302614 might, on the contrary, elevated the risk for completed suicide, but odds ratio (OR) could not be calculated since none CC carrier was detected among suicide attempters (Table 5 ) Furthermore, in ODC1 gene, examination of haplotype rs1049500-rs2302614 associations with suicidal behavior revealed marginal significance of AC haplotype in decreasing the risk for completed suicide compared to suicide attempt (OR = 0.50, F = 0.046, t = 3.79, P = 0.052, logistic regression analysis adjusted by sex) (Table 6 ) Discussion In this study, we report the results of the investigation of five variants from three candidate genes, GRIN2B , GABRG2 and ODC1 , on two types of suicidal behavior, attempted and completed suicide from two Balkan countries, Serbia and Slovenia.

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