Association of placental mitochondrial DNA mutations on infant negative affectivity: modifying effects of maternal lifetime stress and infant sex.

Biol Sex Differ · 2025 · PMC12150558 · PMID 40495250

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closest p · 1.2× alpha

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borderline significantp = 0.06so close (0.05 < p ≤ 0.1)

Interaction between MT_DLOOP and child sex on negative affect When looking at specific mutations, there was a significant interaction between MT_DLOOP mutational load and child sex (β = −0.194, p = 0.009) and a borderline significant interaction between MT_ND, mutational load and child sex (β = −0.135, p = 0.06), indicating that these relationships varied by child sex.

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