Compressive Forces Induce Epigenetic Activation of Aged Human Dermal Fibroblasts Through ERK Signaling Pathway.

Aging Cell · 2025 · PMC12151880 · PMID 40080399

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an increasing trendno p-value reported

We also validated our findings in an artificial aged skin model and observed an increasing trend in collagen I protein levels in the spheroid injection group compared to the single‐cell injection group.

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