Telomere Position Effect-Over Long Distances Acts as a Genome-Wide Epigenetic Regulator Through a Common Alu Element.

Methylation analysis of 850 K CpGs across the genome revealed an overall trend towards hypermethylation in cells with shorter telomeres (Figure S3a ), without overrepresentation of specific regions (e.g., CpG island) nor functional elements (e.g., 3′UTRs, TSS; Figure S3b,c ).

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