Protection against APOE4-associated phenotypes with the longevity-promoting intervention 17α-estradiol in middle-aged male mice.

APOE4 mice show a nonsignificant trend of shorter path lengths, however relative levels of reduction over the training days (i.e., learning) trend in favor of APOE3 mice (control: 20.4% ± 9.1, 17αE2: 17.4% ± 7.7 reductions) versus APOE4 mice (control: 10.3% ± 6.5, 17αE2: 5.2%± 3.7 reductions).

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