Since significant filter fouling impacts with 10,000 g and 100,000 g pellet fractions in the offline small‐scale model were seen at spike concentrations > 4X, the antifoam concentrations in the spiking studies might be significant (> 20−100 ppm).
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Systematic Investigation of Impact of Antifoam and Extracellular Vesicles on Fouling of Hollow Fiber Filters in Intensified Perfusion Processes Highlights the Key Impact of Antifoam.
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