While the ADC Adup variants show an overall trend of increasing resistance to larger cephalosporins, cefiderocol is largely spared from the gain in resistance by the Adup variants, as all tested ADC variant isolates are in the susceptible range (≤4 mg/L) ( Table 1 ) ( 38 ).
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Resistance to oxyimino-cephalosporins conferred by an alternative mechanism of hydrolysis by the <i>Acinetobacter</i>-derived cephalosporinase-33 (ADC-33), a class C β-lactamase present in carbapenem-resistant <i>Acinetobacter baumannii</i> (CR<i>Ab</i>).
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