Idebenone Mitigates Traumatic-Brain-Injury-Triggered Gene Expression Changes to Ephrin-A and Dopamine Signaling Pathways While Increasing Microglial Genes.

Notably, although the Comt mRNA level for the TBI + idebenone group represented only a 1.16-fold increase compared to TBI + vehicle, the difference was still highly significant ( p < 0.001) owing to the low variability across individual mice.

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The next three candidate transcriptional regulators showed marginal significance ( Figure 10 d, p < 0.05, p -adj < 0.1) and are predicted to target fewer of the idebenone-altered gene set.

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