Regional and whole-brain neurofunctional alterations during pain empathic processing of physical but not affective pain in migraine patients.

APc in MIG patients [accuracy 76% ± 9.3% SE, Cohen's d = 0.72, sensitivity: 76%, specificity 76%, two-sided binomial test P = 0.026] with a trend towards significance for CTRL group [accuracy: 71% ± 9.9% (SE), Cohen's d = 0.59, sensitivity 71%, specificity: 71%, two-sided binomial test: p = 0.078].

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Interestingly, our results also showed that patients with MIG presented slightly higher scores on the empathy scale (i.e., BES) than the CTRL group, with a borderline significant difference in the cognitive dimension of empathy.

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Similarly, the beta values extracted from the L IFG [χ 2 (39) = 5.97, p = 0.052, Nagelkerke R2 = 0.177] were marginally significant.

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