ATP/P2X7 receptor/NLRP3 pathway facilitates renal tubular epithelial-myofibroblast transdifferentiation and interstitial fibrosis in rats with unilateral ureteral obstruction.

Front Pharmacol · 2025 · PMC12163002 · PMID 40520155

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a decreasing trendno p-value reported

However, no significant alterations were noted in the ATP concentrations in the obstructed kidney tissue following BBG treatment, even though a decreasing trend was observed. 3.3 BBG alleviated renal TEMT and interstitial fibrosis UUO is a typical model of renal interstitial fibrosis and it has been thoroughly examined by several studies in the past.

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