Adult-onset hypothyroidism induces granulosa cell apoptosis and affects ovarian follicle development in rats.

After for 4 weeks inducation, we found the thyroids were significantly enlarged in the hypothyroidism (hypo) group, while H&E staining showed that the volume of thyroids follicles were significantly smaller than that in the control group, and the colloid in the follicular cavities were reduced ( Figure 1A ), while the body weight of the hypo group were significantly lower than that of the control group and showed a decreasing trend starting from the third week ( Figure 1B ).

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