Global T-cell functionality evaluated by whole blood interferon-gamma release assay as a valuable indicator for immune reconstitution monitoring in pediatric allo-HSCT.

Furthermore, our WB-IGRA results clearly indicated an increasing trend in T-cell functionality among pediatric allo-HSCT patient groups, from immunosuppressants use (in use), to reduced usage (decrease in use) and ultimately discontinuation (out of use) ( Figure 1B ).

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