Musclin Counteracts Skeletal Muscle Dysfunction and Exercise Intolerance in Heart Failure With Preserved Ejection Fraction.

There were no differences in the Npr1 / Npr3 ratio between untreated HFpEF and Sham mice; however, this ratio was significantly increased by 43% in the soleus muscle of musclin-treated versus untreated HFpEF mice ( P =0.027; Figure 3 E), driven mainly by a decreasing trend in Npr3 gene expression in musclin-treated HFpEF mice ( P =0.146; Figure S3 ), suggesting that exogenous musclin increased NP signaling activity.

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