IL-7-mediated expansion of autologous lymphocytes increases CD8+ VLA-4 expression and accumulation in glioblastoma models.

We observed a small trend toward prolonged survival when combining IL-7 ALT with αPD-1 therapy (2 of 6 mice surviving more than 30 days, 0 of 6 with long-term overall survival), but a significant increase in survival when combining IL-7 ALT + α4-1BB compared with IL-7 ALT only ( Figure 2D , * P < 0.05).

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Differential expression analysis also revealed a highly significant outlier when expanding with IL-2 vs IL-7.

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