Integrated analysis of oral rinse-derived and plasma circulating tumour DNA for mutation profiling and outcome prediction with oral squamous cell carcinoma.

Similarly, while univariate analysis revealed associations between ctDNA concentration and clinical features (lymph node metastasis with oral rinse-derived ctDNA, p = 0.012; tumor site and T stage with plasma ctDNA, p = 0.010 and p = 0.032, respectively), multiple linear regression modeling for both oral rinse ( R 2 = 0.109) and plasma (R2 = 0.212) ctDNA did not demonstrate strong associations between baseline ctDNA values and these clinical features, although lymph node metastasis remained significant in oral rinse ( p = 0.006) and tumor site remained marginally significant in plasma ( p = 0.029) multivariate models (Supplementary Tables 4 , 5 ).

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T stage and lymph node metastasis showed marginal significance in plasma ctDNA multivariate models ( p = 0.093) (Supplementary Tables 2 , 3 ).

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Mutational profile association with clinicopathological features and impact of treatment on mutation spectrum In the analysis of the 7-gene panel ( TP53 , TERT , IKZF1 , EP300 , MYC , EGFR and PIK3CA ) mutation spectrum and clinicopathological features in 123 OSCC patients, we identified two key gene mutations significantly associated with specific clinical characteristics, with an additional gene mutation showing borderline significance.

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