Oncology Dose Optimization: Tailored Approaches to Different Molecular Classes.

For molecules with novel and complex MOA (e.g., ADCs, TCEs), there is an increasing trend for these molecules to adopt multiscale mechanistic QSP models to support dosage selection. 18 , 24 These models play a pivotal role in guiding data‐driven dose decisions throughout development, from first‐in‐human starting doses to expansion doses and recommended Phase II/III doses.

also in 63,971 other papers