Tirzepatide, a dual GIP/GLP1-receptor co-agonist preserves cardiac function and improves survival in angiotensin II-induced heart failure model in mice: comparison to liraglutide.

Nevertheless, based on literature data, the angiotensin II-induced inflammatory reaction has a rapid time course, with inflammatory markers showing a decreasing trend after 7 days, while pro-fibrotic factors became more pronounced at the later stages [ 37 ].

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