KO chow mice displayed significant increases in hepatic gluconeogenesis (V Enol ), endogenous glucose production (EndoRa), and citrate synthase (V CS ) flux compared to WT chow mice, whereas these differences did not achieve significance in WT WD mice ( Figure 6A ).
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Simultaneous in vivo multi-organ fluxomics reveals divergent metabolic adaptations in liver, heart, and skeletal muscle during obesity.
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