Preserving Neuronal Chemical Messengers: Heat Stabilization Versus Snap Freezing for Improved MALDI Mass Spectrometry Imaging of Brain Tissues.

Subsequent statistical analysis using the nonparametric Mann–Whitney U ‐test displayed in the aforementioned regions modified levels of neurotransmitters without statistical significance but with an increasing trend in the abundance of DA and 5‐HT (Figure 5 , Figure S13 ) and their metabolites, including DOPAL, DOPAC, HVA, NE, and 5‐HIAA, mainly in anesthetized animals (Figure S13 ). 4.

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