a statistical trendp = 0.060
Finally, the multivariable Cox-regression OS model utilizing the modified histopathological Ki-67 grading system confirmed grade progression as an independent predictor for death (HR = 7.2, 95% CI: 1.58–32.82; p = 0.011) and demonstrated a statistical trend for TNM stage IV (HR = 4.4, 95% CI: 0.94–20.76; p = 0.060; Table 2 ).