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Alterations in functional and structural connectivity in the 6-OHDA-induced Parkinsonian rat model.

Front Neurosci · 2025 · PMC12170622 · PMID 40529248

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Accordingly, the ipsilateral/contralateral TH+ cell ratio was drastically reduced in the 6-OHDA group (3.7% ± 5.6%) compared to the sham group (97.8% ± 40.1%), with a highly significant difference ( p < 0.001), confirming the severe asymmetry induced by the 6-OHDA lesion ( Table 2 ). 3.2 Functional connectivity For FC analysis, three rats (6-OHDA: n = 1; sham: n = 2) were excluded due to incomplete data; thus, the analysis included 46 rats (6-OHDA: n = 23; sham: n = 23).

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