The APC of the second period (2008 to 2021) was −18.41% (95% CI, −27.02% to −8.79%, p = 0.002), demonstrating a decreasing trend; the incidence decreased from 9.1088 cases per 100,000 population in 2008 to 0.0596 cases per 100,000 population in 2021 ( Figure 4 ). 3.2 The incidence and trends of rubella in different regions from 2004 to 2021 From 2004 to 2021, the average annual incidence of rubella was higher than 5 cases per 100,000 population in seven regions of China.
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Long-term trends in rubella incidence across various regions and age groups in China, 2004-2021.
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