It has been shown that the IRGM gene’s single-nucleotide polymorphism rs4958847 showed a highly significant correlation with the incidence of surgery in ileocolonic CD patients ( 159 ). 5.1.4 Polymorphisms in autophagy and gut microbiota The risk allele ATG16L1 T300A, a single nucleotide polymorphism (SNP) linked to increased CD risk, leads to dysbiosis in mice, causing an increase in Bacteroides and amplifying the Th1 and Th17 immune responses in the gut lamina propria ( 160 ).
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Mechanism of cell death and its application in the repair of inflammatory bowel disease by mesenchymal stem cells.
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