Inhibition of the Sterol Regulatory Element Binding Protein SREBF-1 Overcomes Docetaxel Resistance in Advanced Prostate Cancer.

In contrast, a highly significant correlation was observed between SREBF-1 mRNA expression and GR-selective target gene set activity that was specific to the late-stage CRPC data set. siRNA Knockdown of SREBF-1 Leads to Reduced Viability and Increased Apoptosis in DR Cell Lines To elucidate the functional effect on DR PCa after specific SREBF-1 down-regulation, transient siRNA knockdown was performed in PC3-DR and DU145-DR cells.

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