Real-World Evidence Acceptability and Use in Breast Cancer Treatment Decision-Making in the United States: Call-to-Action from a Multidisciplinary Think Tank.

“ Publish targeted examples demonstrating how clinical knowledge can be advanced through evidence unique to RWE (e.g., “population-bridging,” a short-hand term for evaluating treatment effects in populations not studied in RCT).” Recognizing an increasing trend in the volume of RWE published, amplification of select RWE use cases is necessary, specifically those demonstrating unique value relative to RCTs, such as—but not limited to—outcomes in subgroups or local populations typically underrepresented or excluded from RCT, and confirmatory evaluation of efficacy or safety, as observed in the real world [ 5 , 10 , 60 ].

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