Sleep deficiency exacerbates periodontal inflammation via trigeminal TRPV1 neurons.

Proc Natl Acad Sci U S A · 2025 · PMC12184432 · PMID 40489620

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may be significantno p-value reported

Given the hypothalamus’s role as a central regulator for sleep and circadian rhythms, future studies should investigate the neural pathways interconnecting the hypothalamus and trigeminal ganglia, which may be significant in the exacerbation of periodontitis induced by sleep restriction.

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