Ligand-specific regulation of a binary enhancer code dictating cellular senescence.

Proc Natl Acad Sci U S A · 2025 · PMC12184664 · PMID 40493192

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highly significantno p-value reported

We observed highly significant changes in A/B compartmentalization during replicative senescence, which were robustly conserved in rapamycin-withdrawn cells and reversed upon p65 inhibition or by rapamycin treatment ( SI Appendix , Fig.

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