Acidosis attenuates the hypoxic stabilization of HIF-1α by activating lysosomal degradation.

Using a list of 508 proteins with half-life <8 h ( Li et al., 2021 ), enrichment analysis (Fisher’s exact test) found no significant associations under either acidosis or hypoxia analysed separately, but a highly significant association (P < 0.0001) under acidotic hypoxia, specifically among downregulated proteins.

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