Comprehensive DSRCT multi-omics analyses unveil CACNA2D2 as a diagnostic hallmark and super-enhancer-driven EWSR1::WT1 signature gene.

Cancer Commun (Lond) · 2025 · PMC12187571 · PMID 40088092

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highly significantno p-value reported

Notably, fast gene set enrichment analysis (fGSEA) of the CACNA2D2 gene set demonstrated a highly significant ( Padj < 0.001) and strong positive enrichment for the EWSR1::WT1 signature (normalized enrichment score, NES EWSR1::WT1 = 3.6).

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