Transport of the uremic toxin symmetric dimethylarginine (SDMA) by renal transport proteins.

Amino Acids · 2025 · PMC12187869 · PMID 40555835

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highly significantno p-value reported

Therefore, we used custom-synthesized, radiolabeled SDMA for uptake experiments in HEK293 cell lines recombinantly overexpressing renally expressed transport proteins and were able to determine highly significant net uptake mediated by CAT1, OATP4C1, OCT2, and MATE1 (Fig. 1 ).

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