Selective CBP/EP300 Bromodomain Inhibitors: Novel Epigenetic Tools to Counter TNF-α-Driven Inflammation.

JACS Au · 2025 · PMC12188386 · PMID 40575322

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Promisingly, CBP/EP300-BRD inhibition led to a strong and highly significant reduction in the TNF-α-induced expression of il1 β, il 8, mcp-1 and tnf -α ( Figures b and S4 ).

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