Multi-Omics Identification of <i>Fos</i> as a Central Regulator in Skeletal Muscle Adaptation to Long-Term Aerobic Exercise.

Correlation analysis revealed ( Figure 6 D) a statistically significant relationship between Fos and Th1 cells (r = −0.287, p < 0.05), while the correlation between Fos and Treg cells was near marginal significance (r = −0.196, p = 0.12).

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The analysis revealed significant changes in proportions within the Satellite, SM_IPC, and FAP subpopulations, with the TC group showing an increasing trend in Satellite ( p = 0.289) and SM_IPC ( p = 0.158) cell subpopulations.

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For acute exercise: 5 min at 5 m/min, then 5 min at 8 m/min, followed by 2 m/min increments every 15 min until exhaustion, 5° incline), in which those exhibiting trends consistent with the training set and showing marginally significant differences in adjusted p -values (adj.P.Val < 0.15) were considered successfully validated.

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