Lysosomal zinc nanomodulation blocks macrophage pyroptosis for counteracting atherosclerosis progression.

To identify the inflammation/pyroptosis-related gene expression dynamics along the pseudotime trajectories, we explored DEMs that constantly increased or decreased during AS development, where we classified six grouped gene modules based on their expression changes and found that the inflammation/pyroptosis-related genes (such as Gzma , Gzmb , Pgs1 , and Timp1 ) exhibited a decreasing trend after MLs treatment ( Fig. 4, H to J ).

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