Another study utilizing whole-transcriptome sequencing technology discovered a novel tRF, tRF-3022b, which shows an increasing trend in colorectal cancer (CRC) tissues compared to adjacent normal tissues. tRF-3022b plays a vital role in apoptosis inhibition and CRC progression through the regulatory pathway by binding to galectin 1 (LGALS1) and macrophage migration inhibitory factor (MIF) in CRC cells [ 69 ].
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