<i>TGFB2</i> Gene Methylation in Tumors with Low CD8<sup>+</sup> T-Cell Infiltration Drives Positive Prognostic Overall Survival Responses in Pancreatic Ductal Adenocarcinoma.

Genes were filtered based on the tumor-specific expression patterns and Cox models with highly significant interaction terms to identify mRNA expression of genes that amplified the impact of TGFB2 methylation.

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There was a borderline significant difference in OS outcomes when comparing RAC2 low / TGFB1 lowMe ( n = 40, mOS = 66.9 months) versus RAC2 low / TGFB1 highMe ( n = 48, mOS = 19.4 months, OS difference = −47.4, p = 0.051) groups of patients ( Figure S7D ).

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