Targeting COL5A1 enhances anoikis thus attenuating malignancy of glioblastoma via inhibiting the Wnt/β-catenin signaling pathway.

Key genes were identified based on specified thresholds for module membership score (MM ≥ 0.8) and gene significance score (GS ≥ 0.2) within both modules; COL5A1 emerged as highly significant across both databases as depicted in Fig. 1 G-I.

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