MTAP immunohistochemistry as a surrogate marker of CDKN2A loss in brain tumors: A meta-analysis and literature review.

CDKN2A , a tumor suppressor gene that is highly significant in both the p53 and RB1 cell cycle pathways, is found in the short arm of chromosome 9 (9p21) and encodes the protein p16INK4a or INK4a (inhibitor of kinase 4a). 3 The 5′-methylthioadenosine phosphorylase ( MTAP ) is a tumor suppressor gene located adjacent to the CDKN2A gene on chromosome 9p21 tha

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