Peak width of skeletonized mean diffusivity mediates the relationship between cerebral small vessel disease burden and cognitive impairment in community-dwelling older adults.

Brain Commun · 2025 · PMC12203534 · PMID 40585818

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0.0530

closest p · 1.1× alpha

0.0530

boldest claim

The sentences

marginally insignificantP = 0.053so close (0.05 < p ≤ 0.1)

After adjusted for age, sex, education level and APOE ɛ4 in multivariate linear regression models, PSMD ( β = −0.28, P = 0.015), CMB numbers ( β = −0.07, P < 0.001) and WMHV ( β = −0.03, P = 0.003) remained negatively correlated with the MMSE score, while CSVD burden exhibited a marginally insignificant correlation with the MMSE score ( β = −0.20, P = 0.053).

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