An increasing trend in DKD incidence according to data estimation from the International Diabetes Federation indicates that approximately 366 million cases of DM will be present in 2030 [ 4–6 ].
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Glomerular mesangial derived extracellular vesicles deteriorate diabetic kidney disease via miR-3147/PRKAR2B axis.
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Therefore, it is reasonable to observe a decreasing trend and difference in HbA1c between DM patients and DKD patients.