111 , 112 Our RNA-seq analysis revealed highly significant DEGs unique to the AD group, including those related to the complement system ( CX3CL1 ) and mitochondrial function and autophagic processes ( HGMCS2 ), both previously implicated in AD pathology. 42 , 43 , 47 , 48 While control brain extracts induced some overlapping gene expression which might reflect effects of other protein components in the sarkosyl-insoluble fraction, AD brain extracts produced a higher number of DEGs with a larger effect size.
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Alzheimer's disease brain-derived tau extracts show differential processing and transcriptional effects in human astrocytes.
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