Prediction of methotrexate neurotoxicity using clinical, sociodemographic, and area-based information in children with acute lymphoblastic leukemia.

Methotrexate dosing ≥1 g/m 2 was also a highly significant ( P < .01) and important predictor in our study and was associated with a nearly two-fold (OR = 1.73, 95% CI: 1.07-2.82) odds of neurotoxicity compared to doses <1 g/m 2 in adjusted logistic models.

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