Barely Significant
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Directed evolution of metalloproteinase inhibitor TIMP-1 for selective inhibition of MMP-9 exploits catalytic and fibronectin domain interactions.

J Biol Chem · 2025 · PMC12206030 · PMID 40409544

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highly significantp < 0.0001actually significant
Two-way ANOVA analysis revealed highly significant main effects of TIMP-1 concentration ( p < 0.0001 in both cell lines), indicating robust dose-dependent suppression of invasion.

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