Valproic acid exposure alters histone deacetylase mRNA expression profile in oral cancer and premalignant cell lines.

Biomed Rep · 2025 · PMC12207727 · PMID 40589717

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borderline significantno p-value reported

Increased HDAC4 and HDAC5 and decreased HDAC7 mRNA expression was observed across the cell lines, while no consistent, except borderline significant, changes were caused to HDAC9 mRNA expression following VPA treatment compared with controls ( Fig. 1 ).

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