Overlapping genes connect rheumatoid arthritis and head and neck cancer: coincidence or shared immune pathophysiology?

Front Med (Lausanne) · 2025 · PMC12213867 · PMID 40606440

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highly significantno p-value reported

HNC positively influences the transcription factor RELA (4 references; q = 0.0032), which in turn strongly promotes RA (16 references; q = 2.93 × 10 −12 ), indicating a highly significant and reinforcing HNC → RELA → RA pathway.

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