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<i>SIRT2</i>-dependent <i>CPT1A</i> deacetylation in macrophages inhibits periodontitis.

Front Pharmacol · 2025 · PMC12213876 · PMID 40606607

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a pronounced trendno p-value reported
gingivalis-LPS significantly increased the levels of inflammatory markers in macrophages, with IL-6 mRNA levels increasing by 50 folds (p < 0.0001), TNF-α mRNA levels increasing by 20 folds (p < 0.0001), and IL-1β mRNA levels increasing by 20 folds (p < 0.0001), indicating a pronounced trend toward inflammatory polarization, as displayed in Figures 3a–c .

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