Rhaponticin inhibits the proliferation, migration, and invasion of head and neck squamous cell carcinoma (HNSCC) cells through modulation of the IL6/STAT3 signaling pathway.

Discov Oncol · 2025 · PMC12214110 · PMID 40591033

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highly significantno p-value reported

These cytokines further activate a variety of signaling pathways, including the JAK/STAT3 and TNF signaling pathways, playing a highly significant role in tumor recurrence and metastasis [ 25 , 26 ].

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