Bioinformatic and genomic analysis identifies C allele of APOE rs7412 as the most prominent variant limiting extreme human longevity.

Sci Rep · 2025 · PMC12215757 · PMID 40594060

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highly significantno p-value reported

For example, the SNP rs16991615 in the MCM8 gene had an odds ratio (OR) of 0.93, while rs11668344 in TMEM150B showed an OR of 0.43, both with highly significant p-values.

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